Sisley has revealed the latest addition to its anti-ageing line, called the Sisleÿa Longevity Essential Serum.
According to the Maison, the launch follows recent scientific insights into how biological ageing affects the skin and highlights the role of interconnected systems in maintaining skin health.
Sisley’s research indicates that in mature skin, the three systems key to a youthful appearance (the cutaneous system, the vascular system and the immune system) weaken and lose their ability to communicate. With the new serum, the house seeks to reactivate communication between them and stimulate each individually.
Testing showed improvements across all three systems, including a 72% reduction in the diameter of slackened lymphatic vessels, a 46% strengthening of vascular cell junctions, a 15% reduction in senescent cells and a 45% increase in immune cells.
The formula also includes a new Gingko extract aimed at strengthening the immune system. It works by countering “immune evasion,” the phenomenon where senescent fibroblasts avoid elimination and spread ageing signals. In addition, Sisley’s Phyto-chemistry Laboratories have created a duo of plant-based actives targeting skin thinning and yellowing, complemented by a red algae extract to reduce glycation. Red Vine extract is included to address grey skin tones and improve radiance.
To demonstrate efficacy, Sisley used a vascularised 3D skin model that incorporated immune cells. Testing showed improvements across all three systems, including a 72% reduction in the diameter of slackened lymphatic vessels, a 46% strengthening of vascular cell junctions, a 15% reduction in senescent cells and a 45% increase in immune cells. Clinical trials involving more than 90 participants further supported the findings. After two months, skin firmness improved with an anti-ageing index score increase of 28%. Users reported reductions in wrinkles, yellowing and sagging, alongside improved radiance and smoothness.
The serum is designed to be used within the Sisleÿa routine, positioned between the lotion and existing serums. Sisley emphasises that it is not a replacement but a complementary step for supporting long-term skin health and longevity.
